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Project Information

ROLE OF MILK-BORNE FACTORS IN NEONATAL REPRODUCTIVE TRACT DEVELOPMENT

Agency:
NIFA

USDA/National Institute of Food and Agriculture

Project Number:
1010235
Contact PI / Project Leader:
BAGNELL, CA, A.
Awardee Organization:
RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

Description

Abstract Text:
The long-term goal of the proposed research is to advance understanding of the developmental origins of adult disease by testing the lactocrine hypothesis for maternal programming of female reproductive tract development. Maternal influence over offspring development extends beyond the womb into neonatal life by way of nursing. For newborn mammals, both human and animal, consumption of 'first milk' (colostrum) soon after birth delivers nutrients and milk-borne factors (MbFs) to offspring that can affect the way that reproductive tissues develop and function in adults. Little is known about these MbFs and how they affect development. Colostrum and milk are produced during lactation and delivery of MbFs from mother to infant via nursing is called lactocrine transmission.The global impact of age and lactocrine signaling on uterine microRNA gene expression will be studied. We will then investigate the long-term effects of low vs high colostrum consumption on the porcine uterus at postnatal Day 14 and in the adult in early pregnancy. Finally, we will investigate whether epigenetic changes are occurring in response to age and nursing from birth by monitoring uterine DNA methylation patterns. Proposed research, using a pig model system, will extend our current understanding of maternal programming of reproductive system development by way of nursing and begin to uncover mechanisms responsible for these effects. These studies will contribute mechanistic information about how breastfeeding supports reproductive health and development of human infants. In addition, information gained from these studies could lead to improvements in husbandry guidelines designed to optimize reproductive performance in the pig, an economically important domestic animal.
Project Terms:
Adult; Affect; Age; Animals; Barker Hypothesis; Biological Models; Birth; Breast Feeding; Colostrum; Consumption; design; Development; Discipline of Nursing; DNA Methylation; Domestic Animals; Epigenetic Process; Family suidae; Female; Gene Expression; Goals; Guidelines; Human; Infant; Lactation; Lead; Life; Long-Term Effects; Mammals; methylation pattern; MicroRNAs; Milk; Mothers; Neonatal; Newborn Infant; Nutrient; offspring; Performance; postnatal; Pregnancy; programs; reproductive; Reproductive Health; Reproductive system; reproductive tract; Research; response; Role; Signal Transduction; Systems Development; Testing; Tissues; transmission process; Uterine Monitoring; Uterus

Details

Contact PI / Project Leader Information:
Name:  BAGNELL, CA, A.
Other PI Information:
Not Applicable
Awardee Organization:
Name:  RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK
City:  NEW BRUNSWICK    
Country:  UNITED STATES
Congressional District:
State Code:  NJ
District: 
Other Information:
Fiscal Year: 2016
Award Notice Date:
DUNS Number: 001912864
Project Start Date: 21-Jul-2016
Budget Start Date:
CFDA Code: 10.203
Project End Date: 14-Jul-2021
Budget End Date:
Agency: ?

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USDA/National Institute of Food and Agriculture
Project Funding Information for 2016:

No funding information available for Project Number: 1010235

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