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Project Information

IDENTIFICATION AND MECHANISM OF ANTI-OBESITY PHYTOCHEMICALS IN FOODS

Agency:
NIFA

USDA/National Institute of Food and Agriculture

Project Number:
1007898
Contact PI / Project Leader:
HO, C, .
Awardee Organization:
RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

Description

Abstract Text:
The increasing prevalence of obesity is happening not only in the United States but also worldwide. According to WHO data, the prevalence of obesity has doubled since 1980. Almost 65% of the world's population lives in countries where overweight and obesity kills more people than underweight. Today, obesity affects not only adults but also children; 15-20% of children and adolescents are obese in the United States. Obesity is a serious h ealth problem worldwide. The primary cause of obesity is an energy imbalance. When energy intake is more than energy expenditure, the excess energy could be stored as triacylglycerol in the adipocytes. This excess energy can increase the number and size of adipocytes, eventually expanding the adipose tissue. Adipose tissue can be deposited under the skin and in the intra-abdominal area. More and more research has shown that adipose tissue is an endocrine organ that can regulate the whole-body energy homeostasis through the secretion of various adipose-derived hormones or adipokines and affects the function of other organs, such as the brain, liver, pancreas, and skeletal muscle. Therefore, obesity plays a key role in metabolic syndromes and is highly related to diabetes, cardiovascular disease, and cancer. The National Institutes of Health has developed some strategic plans for obesity research, including the discovery of biological mechanisms regulated to energy balance; understanding of the correlates, determinants, and consequences of obesity; the design and testing of interventions to promote healthy weight; the dissemination and implementation of research; and improvements in measurement tools, technology, and methods. Their ultimate goal is to prevent and treat obesity efficiently. Recently, researchers have been more interested in the role of natural compounds such as epigallocatechin-3-gallate from green tea, raspberry ketones from raspberries, and synephrine from orange in regulating lipid metabolism to decrease adipogenesis in vivo or in vitro.Our proposed research is seeking novel compounds from fruits and vegetables which have anti-adipogenic and anti-obesity activity and study their mode of actions.
Project Terms:
Adipocytes; adipokines; Adipose tissue; Adolescent obesity; Adult; Affect; Area; Biological; Brain; Cardiovascular Diseases; Child; Country; Data; Deposition; design; Diabetes Mellitus; Endocrine Glands; energy balance; Energy Intake; Energy Metabolism; Epigallocatechin Gallate; Food; fruits and vegetables; Goals; Green tea; healthy weight; Homeostasis; Hormones; implementation research; In Vitro; in vivo; interest; Intervention; Intra-abdominal; Ketones; Killings; lipid biosynthesis; lipid metabolism; Liver; Malignant Neoplasms; Measurement; Metabolic syndrome; Methods; novel; Obesity; Oranges; Organ; Overweight; Pancreas; Phytochemical; Play; Population; Prevalence; prevent; Raspberries; Research; Research Personnel; Role; Skeletal Muscle; Skin; Strategic Planning; Technology; Testing; tool; Triglycerides; Underweight; United States; United States National Institutes of Health

Details

Contact PI / Project Leader Information:
Name:  HO, C, .
Other PI Information:
Not Applicable
Awardee Organization:
Name:  RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK
City:  NEW BRUNSWICK    
Country:  UNITED STATES
Congressional District:
State Code:  NJ
District: 
Other Information:
Fiscal Year: 2016
Award Notice Date:
DUNS Number: 001912864
Project Start Date: 20-Oct-2015
Budget Start Date:
CFDA Code: 10.203
Project End Date: 30-Sep-2020
Budget End Date:
Agency: ?

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USDA/National Institute of Food and Agriculture
Project Funding Information for 2016:

No funding information available for Project Number: 1007898

Results

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