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Project Information

REGULATION OF DIETARY LIPID IN INTESTINAL CELLS: INTESTINAL FATTY ACID-BINDING PROTEINS AND WHOLE BODY ENERGY HOMEOSTASIS

Agency:
NIFA

USDA/National Institute of Food and Agriculture

Project Number:
1003608
Contact PI / Project Leader:
STORCH, J, .
Awardee Organization:
RBHS -CANCER INSTITUTE OF NEW JERSEY

Description

Abstract Text:
Free fatty acids (FA) and monoacylglycerol (MG) are the hydrolysis products of dietary triacylglycerol (TG). They constitute not only a major source of calories, but are also precursors of many biologically active molecules and are incorporated as structural components of cellular membranes. The mechanisms which regulate the uptake and intracellular movement of FA and MG in intestinal cells remain largely unresolved. The ultimate goal of this work is to understand and thereby be able to regulate the influx, efflux, and intracellular targeting of FA and MG. This research will define the mechanisms by which dietary fat is taken up and processed by intestinal cells, and will provide an understanding of how the uptake of lipid can be regulated-either to decrease uptake, as in the case of caloric reduction, or to increase uptake, in the case of nutrient malabsorption. Such an understanding will not only enhance our knowledge of the basic mechanisms of utilization of a major nutrient, triacylglycerol, but will enable more effective regulation of net intestinal lipid uptake. This will have important implications for the treatment of obesity and malabsorptive disorders, and will assist in the development of effective enteral drug delivery systems.
Project Terms:
Calories; Cells; Cellular Membrane; Development; Diet; Dietary Fats; Disease; Drug Delivery Systems; Enteral; Fatty Acids; Goals; Homeostasis; Hydrolysis; intestinal fatty acid binding protein; Intestines; Knowledge; Lipids; Malabsorption Syndromes; Monoglycerides; Movement; Nonesterified Fatty Acids; Nutrient; obesity treatment; Process; Regulation; Research; Source; Triglycerides; uptake; Work

Details

Contact PI / Project Leader Information:
Name:  STORCH, J, .
Other PI Information:
Not Applicable
Awardee Organization:
Name:  RBHS -CANCER INSTITUTE OF NEW JERSEY
City:  NEW BRUNSWICK    
Country:  UNITED STATES
Congressional District:
State Code:  NJ
District: 
Other Information:
Fiscal Year: 2015
Award Notice Date:
DUNS Number: 078728091
Project Start Date: 01-Oct-2014
Budget Start Date:
CFDA Code: 10.203
Project End Date: 30-Sep-2019
Budget End Date:
Agency: ?

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USDA/National Institute of Food and Agriculture
Project Funding Information for 2015:

No funding information available for Project Number: 1003608

Results

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