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Project Information

GLUTAMINE AND LIPID METABOLISM

Agency:
NIFA

USDA/National Institute of Food and Agriculture

Project Number:
1002558
Contact PI / Project Leader:
WATFORD, M, .
Awardee Organization:
RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

Description

Abstract Text:
The work will determine the role of the amino acid glutamine in fat metabolism during both obesity and also during lactation. We have evidence that glutamine availabilty with fat contributes to the health of the fat tissue in lean inviduals, but may be deterimental in the obese. We will test this by looking at how glutamine acts to improve the health of small (lean) fat cells and also how it provides a fuel to invading inflammatory macrophages (immune cells) in obesity that then leads to insulin resistance and Type 2 diabetes. This work will establish if glutamine is used to synthesize different forms of fat in adipose tissue and will be complemented by comparison to other tissues such as liver and lactating mammary gland. A second line of investigation will be to investigate the beneficial effects of dietary glutamine supplementation on the health of lactating mothers and the well-being of the offspring. In this phase of work, both pigs and mice will be used and we will determine how supplemental glutamine gives rise to high levels of fat in the milk, and so links to the work described above with fat tissue. The final phase of work will use molecular biological tecniques to prevent glutamine synthesis in specific organs (fat, liver, mammary gland) of the body and so identify potential sites of intervention to both prevent the complications of obesity and to improve performance and development in lactation.
Project Terms:
Adipocytes; Adipose tissue; Amino Acids; Biological; Cells; Complement; Development; Diet; Family suidae; Fatty acid glycerol esters; Glutamine; Health; Immune; improved; Inflammatory; Insulin Resistance; Intervention; Invaded; Investigation; Lactation; Link; lipid metabolism; Liver; macrophage; Mammary gland; Milk; Molecular; Mothers; Mus; Non-Insulin-Dependent Diabetes Mellitus; Obesity; offspring; Organ; Performance; Personal Satisfaction; Phase; prevent; Role; Site; Supplementation; Testing; Tissues; Work

Details

Contact PI / Project Leader Information:
Name:  WATFORD, M, .
Other PI Information:
Not Applicable
Awardee Organization:
Name:  RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK
City:  NEW BRUNSWICK    
Country:  UNITED STATES
Congressional District:
State Code:  NJ
District: 
Other Information:
Fiscal Year: 2014
Award Notice Date:
DUNS Number: 001912864
Project Start Date: 19-Mar-2014
Budget Start Date:
CFDA Code: 10.203
Project End Date: 28-Feb-2019
Budget End Date:
Agency: ?

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USDA/National Institute of Food and Agriculture
Project Funding Information for 2014:

No funding information available for Project Number: 1002558

Results

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