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Project Information

I-CORPS: COMMERCIALIZATION OF RADIO-CARBON ANALYZER FOR BIOMEDICAL APPLICATIONS

Agency:
NSF

National Science Foundation

Project Number:
1443530
Contact PI / Project Leader:
MURNICK, DANIEL E
Awardee Organization:
RUTGERS THE STATE UNIV OF NJ NEWARK

Description

Abstract Text:
The team has developed a new method for ultrasensitive radiocarbon detection. The laser-based technology allows the measurement of trace amounts, on the order of one part per one trillion, of radioactive label in organic compounds. The proposed analyzer has the potential to change the way the pharmaceutical industry conducts metabolic and toxicity studies with radio-labeled carbon for its drug discovery and development programs long before human clinical trials. A commercialized version of this analyzer technology would enable scientists to conduct ultrasensitive measurements more quickly on-site and with small samples and thus less radioactivity.

Existing Accelerator Mass Spectrometer technology effectively counts atoms as they are accelerated across a large equipment platform that takes up a large room and is expensive to maintain. It is complex and expensive; only a few such systems exist for the purposes of Biological Radiocarbon studies, and samples must be outsourced to such facilities with long turnaround times. Existing Liquid Scintillation Counter (LSC) technology must use samples 3-4 orders of magnitude larger with much higher radiation because the beta-decay counting technique lacks the sensitivity for many metabolic and toxicity studies. The proposed laser based technology effectively tickles the CO2 molecules with a laser millions of times per second in an electrical discharge and obtains an electronic response (known as the Optogalvanic Effect). The proposed technology has the potential to reduce the costs associated with new drug development by enabling pharmacokinetic studies to be initiated in humans sooner than currently possible and will thus accelerate the time to approval and market.
Project Terms:
base; Biological; Carbon; Carbon Dioxide; Clinical Trials; commercialization; Complex; cost; Detection; drug development; drug discovery; Drug Industry; Drug Kinetics; Electronics; Equipment; Human; Label; Lasers; Liquid substance; Marketing; mass spectrometer; Measurement; Metabolic; Methods; Program Development; Radiation; Radio; Radioactive; Radioactivity; response; Sampling; Sampling Studies; Scientist; Scintillation Counter; Site; System; Techniques; Technology; Time; Toxic effect

Details

Contact PI / Project Leader Information:
Name:  MURNICK, DANIEL E
Other PI Information:
Not Applicable
Awardee Organization:
Name:  RUTGERS THE STATE UNIV OF NJ NEWARK
City:  NEWARK    
Country:  UNITED STATES
Congressional District:
State Code:  NJ
District:  10
Other Information:
Fiscal Year: 2014
Award Notice Date: 03-Jun-2014
DUNS Number: 130029205
Project Start Date: 01-Jul-2014
Budget Start Date:
CFDA Code: 47.041
Project End Date: 31-Dec-2014
Budget End Date:
Agency: ?

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National Science Foundation
Project Funding Information for 2014:
Year Agency

Agency: The entity responsible for the administering of a research grant, project, or contract. This may represent a federal department, agency, or sub-agency (institute or center). Details on agencies in Federal RePORTER can be found in the FAQ page.

FY Total Cost
2014 NSF

National Science Foundation

$50,000

Results

i

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