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Project Information

MOLECULAR MECHANISMS REGULATING SKELETAL MUSCLE GROWTH AND DIFFERENTIATION

Agency:
NIFA

USDA/National Institute of Food and Agriculture

Project Number:
0231763
Contact PI / Project Leader:
ANTHONY, T.
Awardee Organization:
RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

Description

Abstract Text:
The identification of an optimal protein intake level (not a minimal requirement) for health and wellness has yet to be established for animals and humans. Much controversy exists concerning optimal protein nutrition for metabolic health and longevity. On one hand, increased intake of protein is associated with greater lean mass and mitochondrial function. On the other hand, lower protein intake is associated with reduced incidence of chronic disease and recent studies report that diets restricted in one or more essential amino acids reduces fat accumulation and promotes longevity while maintaining lean mass. The regulation of protein synthesis in muscle is key to regulating muscle mass. The eukaryotic translation initiation factors (eIF) and the intracellular signaling pathways associated with their expression and activity are critical regulators of anabolic growth in skeletal muscle. A deeper understanding of the mechanisms by which altered supply of dietary essential amino acids regulates muscle growth when in combination with a high fat diet and/or physical activity is necessary to devise optimal protein nutrition for animal growth and production. Results can be used to refine current diet formulations to maximize muscle mass in domestic animals and thus benefit the meat industry. To achieve this goal, rodent models (control wild type or genetically modified) will be fed diets containing different levels of essential amino acids in combination with different levels of dietary fat and/or physical activity. Body composition and fuel usage will be monitored in live animals and signaling pathways regulating protein synthesis will be assessed at the levels of mRNA and protein expression using standard biochemical and molecular biology approaches in tissues collected at the end of the study.
Project Terms:
Animal Nutrition; Animals; Biochemical; Body Composition; Chronic Disease; Diet; Dietary Fats; dietary restriction; Domestic Animals; Drug Formulations; Essential Amino Acids; Eukaryotic Initiation Factors; Fatty acid glycerol esters; feeding; Goals; Growth; Hand; Health; Human; Incidence; Industry; Intake; Life; Longevity; Meat; Messenger RNA; Metabolic; Mitochondria; Molecular; Molecular Biology; Monitor; Muscle; muscle form; nutrition; Physical activity; Production; Protein Biosynthesis; protein expression; Proteins; Regulation; Reporting; Rodent Model; Signal Pathway; skeletal muscle growth; Tissues

Details

Contact PI / Project Leader Information:
Name:  ANTHONY, T.
Other PI Information:
Not Applicable
Awardee Organization:
Name:  RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK
City:  NEW BRUNSWICK    
Country:  UNITED STATES
Congressional District:
State Code:  NJ
District: 
Other Information:
Fiscal Year: 2013
Award Notice Date:
DUNS Number: 001912864
Project Start Date: 01-Nov-2012
Budget Start Date:
CFDA Code: 10.203
Project End Date: 30-Sep-2015
Budget End Date:
Agency: ?

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USDA/National Institute of Food and Agriculture
Project Funding Information for 2013:

No funding information available for Project Number: 0231763

Results

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