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Project Information

REGULATION OF PHOSPHOLIPID SYNTHESIS

Agency:
NIFA

USDA/National Institute of Food and Agriculture

Project Number:
0188616
Contact PI / Project Leader:
CARMAN, G.
Awardee Organization:
RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

Description

Abstract Text:
Lipids form the structural basis for biological membranes (e.g., phospholipids) and are stored in lipid droplets (e.g., triacylglycerol) as an energy reserve. Their synthesis also prevents toxicity caused by free fatty acids that are consumed in the diet. Defects in the metabolism of lipids lead to a host of diseases such as lipodystrophy, obesity, heart disease, peripheral neuropathy, myoglobinuria, and inflammation. This project focuses on phosphatidate phosphatase, a key enzyme that controls the proportional synthesis of triacylglycerol and membrane phospholipids. Too much activity results in obesity, whereas too little activity results in lipodystrophy. Thus, the goal of the project is to understand how the expression of the enzyme is regulated and how the activity of existing enzyme is regulated. The work will be addressed through biochemical and molecular studies using the simple baker's yeast as a model system. The ultimate goal is to develop practical means to control and/or treat the obese condition in humans.
Project Terms:
Address; base; Biochemical; Biological; Biological Models; Defect; Diet; Disease; Enzymes; Goals; Heart Diseases; Human; Inflammation; Lead; lipid metabolism; Lipids; Lipodystrophy; Membrane; Molecular; Myoglobinuria; Nonesterified Fatty Acids; Obesity; Peripheral Nervous System Diseases; Phosphatidate Phosphatase; Phospholipids; prevent; Regulation; Saccharomyces cerevisiae; Toxic effect; Triglycerides; Work

Details

Contact PI / Project Leader Information:
Name:  CARMAN, G.
Other PI Information:
Not Applicable
Awardee Organization:
Name:  RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK
City:  NEW BRUNSWICK    
Country:  UNITED STATES
Congressional District:
State Code:  NJ
District: 
Other Information:
Fiscal Year: 2012
Award Notice Date:
DUNS Number: 001912864
Project Start Date: 01-Oct-2011
Budget Start Date:
CFDA Code: 10.203
Project End Date: 30-Sep-2016
Budget End Date:
Agency: ?

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USDA/National Institute of Food and Agriculture
Project Funding Information for 2012:

No funding information available for Project Number: 0188616

Results

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