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Project Information

MECHANISMS OF DIETARY LIPID ASSIMILATION IN THE INTESTINE

Agency:
NIFA

USDA/National Institute of Food and Agriculture

Project Number:
0160134
Contact PI / Project Leader:
STORCH, J.
Awardee Organization:
RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

Description

Abstract Text:
Free fatty acids (FA) and monoacylglycerol (MG) are the hydrolysis products of dietary triacylglycerol (TG). They constitute not only a major source of calories, but are also precursors of many biologically active molecules and are incorporated as structural components of cellular membranes. The mechanisms which regulate the uptake and intracellular movement of FA and MG in intestinal cells remain largely unresolved. The ultimate goal of this work is to understand and thereby be able to regulate the influx, efflux, and intracellular targeting of FA and MG. This research will define the mechanisms by which dietary fat is taken up and processed by intestinal cells, and will provide an understanding of how the uptake of lipid can be regulated-either to decrease uptake, as in the case of caloric reduction, or to increase uptake, in the case of nutrient malabsorption. Such an understanding will not only enhance our knowledge of the basic mechanisms of utilization of a major nutrient, triacylglycerol, but will enable more effective regulation of net intestinal lipid uptake. This will have important implications for the treatment of obesity and malabsorptive disorders, and will assist in the development of effective enteral drug delivery systems.
Project Terms:
Assimilations; Calories; Cells; Cellular Membrane; Development; Dietary Fats; Disease; Drug Delivery Systems; Enteral; Fatty Acids; Goals; Hydrolysis; Intestines; Knowledge; Lipids; Malabsorption Syndromes; Monoglycerides; Movement; Nonesterified Fatty Acids; Nutrient; obesity treatment; Process; Regulation; Research; Source; Triglycerides; uptake; Work

Details

Contact PI / Project Leader Information:
Name:  STORCH, J.
Other PI Information:
Not Applicable
Awardee Organization:
Name:  RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK
City:  NEW BRUNSWICK    
Country:  UNITED STATES
Congressional District:
State Code:  NJ
District: 
Other Information:
Fiscal Year: 2010
Award Notice Date:
DUNS Number: 001912864
Project Start Date: 01-Oct-2009
Budget Start Date:
CFDA Code: 10.203
Project End Date: 30-Sep-2014
Budget End Date:
Agency: ?

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USDA/National Institute of Food and Agriculture
Project Funding Information for 2010:

No funding information available for Project Number: 0160134

Results

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