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Project Information

FUNCTION AND REGULATION OF METACASPASES IN PLANT CELL DEATH

Agency:
NSF

National Science Foundation

Project Number:
1258071
Contact PI / Project Leader:
LAM, ERIC
Awardee Organization:
RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

Description

Abstract Text:
Programmed cell death (PCD) is found in all eukaryotes and plays critical roles in important processes such as tissue/organ morphogenesis, elimination of unwanted/damaged cells, pathogen defense, and stress responses. Metacaspases belong to a family of specialized cysteine proteases that are found to be highly conserved regulators of this important process in plants, fungi and protozoa but their mode of regulation and downstream targets remain obscure in most cases. This project will carry out genetic and molecular studies aimed at elucidating the mechanisms by which the activation and desensitization of metacaspases may be controlled. Furthermore, the investigators will deploy a novel technology to define the intracellular targets for three different metacaspases in order to uncover the potential pathways that are regulated by these proteases. In addition to the direct contributions toward our understanding of PCD regulation in higher plants, this project will shed light on the mechanisms of how the conserved metacaspases could be regulated. These advances can facilitate future design of novel strategies to activate cell death in pathogenic protozoa strains and fungi, as well as to suppress cell death in crop plants during stresses for improved productivity.

Results generated from this project will be communicated to the public via peer-reviewed journals, and the resources produced, such as new mutant lines and DNA constructs, will be freely shared with other investigators upon request. From the pedagogical perspective, this project will provide diversified, interdisciplinary training to postdoctoral researchers and students at both the graduate and undergraduate levels. It will expose team members to a diverse array of disciplines, including genetics, genomics, molecular cloning, biochemistry and cell biology. This broad-based training will provide a rich environment that is conducive to creative approaches for solving complex problems in biology and for leveraging innovative technologies for novel solutions.
Project Terms:
Apoptosis; base; Biochemistry; biological adaptation to stress; Biology; Caspase; Cell Death; cell injury; Cellular biology; Complex; Cysteine Protease; desensitization; design; Discipline; DNA; Environment; Eukaryota; Family; fungus; Future; Genetic; Genomics; improved; innovative technologies; Journals; Light; member; Molecular Cloning; Molecular Genetics; Morphogenesis; mutant; new technology; novel; novel strategies; Organ; pathogen; Pathway interactions; Peer Review; Peptide Hydrolases; plant fungi; Plants; Play; Process; Productivity; Protozoa; Regulation; Research Personnel; Resources; Role; Solutions; Stress; Students; Tissues; Training; Vascular Plant

Details

Contact PI / Project Leader Information:
Name:  LAM, ERIC
Other PI Information:
LIU, RIHE
Awardee Organization:
Name:  RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK
City:  NEW BRUNSWICK    
Country:  UNITED STATES
Congressional District:
State Code:  NJ
District:  06
Other Information:
Fiscal Year: 2013
Award Notice Date: 04-Sep-2013
DUNS Number: 001912864
Project Start Date: 15-Sep-2013
Budget Start Date:
CFDA Code: 47.074
Project End Date: 31-Aug-2016
Budget End Date:
Agency: ?

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National Science Foundation
Project Funding Information for 2013:
Year Agency

Agency: The entity responsible for the administering of a research grant, project, or contract. This may represent a federal department, agency, or sub-agency (institute or center). Details on agencies in Federal RePORTER can be found in the FAQ page.

FY Total Cost
2013 NSF

National Science Foundation

$219,000

Results

i

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