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Project Information

SEMANTICS AND SERVICES ENABLED PROBLEM SOLVING ENVIRONMENT FOR TRYPANOSOMA CRUZI

Agency:
NHLBI

HHS/NIH/National Heart Lung and Blood Institute (NHLBI)

Project Number:
1R01HL087795-01A1
Contact PI / Project Leader:
SHETH, AMIT P
Awardee Organization:
WRIGHT STATE UNIVERSITY

Description

Abstract Text:
DESCRIPTION (provided by applicant): The study of complex biological systems increasingly depends on vast amounts of dynamic information from diverse sources. The scientific analysis of the parasite Trypanosoma cruzi (T.cruzi), the principal causative agent of human Chagas disease, is the driving biological application of this proposal. Approximately 18 million people, predominantly in Latin America, are infected with the T.cruzi parasite. As many as 40 percent of these are predicted eventually to suffer from Chagas disease, which is the leading cause of heart disease and sudden death in middle-aged adults in the region. Research on T. cruzi is therefore an important human disease related effort. It has reached a critical juncture with the quantities of experimental data being generated by labs around the world, due in large part to the publication of the T.cruzi genome in 2005. Although this research has the potential to improve human health significantly, the data being generated exist in independent heterogeneous databases with poor integration and accessibility. The scientific objectives of this research proposal are to develop and deploy a novel ontology-driven semantic problem-solving environment (PSE) for T.cruzi. This is in collaboration with the National Center for Biomedical Ontologies (NCBO) and will leverage its resources to achieve the objectives of this proposal as well as effectively to disseminate results to the broader life science community, including researchers in human pathogens. The PSE allows the dynamic integration of local and public data to answer biological questions at multiple levels of granularity. The PSE will utilize state-of- the-art semantic technologies for effective querying of multiple databases and, just as important, feature an intuitive and comprehensive set of interfaces for usability and easy adoption by biologists. Included in the multimodal datasets will be the genomic data and the associated bioinformatics predictions, functional information from metabolic pathways, experimental data from mass spectrometry and microarray experiments, and textual information from Pubmed. Researchers will be able to use and contribute to a rigorously curated T.cruzi knowledge base that will make it reusable and extensible. The resources developed as part of this proposal will be also useful to researchers in T.cruzi related kinetoplastids, Trypanosoma brucei and Leishmania major (among other pathogenic organisms), which use similar research protocols and face similar informatics challenges. PUBLIC HEALTH RELEVANCE: The scientific objective of this proposal is to develop and deploy a novel ontology-driven semantic problem-solving environment (PSE) for Trypanosoma cruzi, a parasite that infects approximately 18 million people, predominantly in Latin America. As many as 40 percent of those infected are predicted to eventually suffer from Chagas disease, the leading cause of heart disease and sudden death in middle-aged adults in the region. Facilitating T.cruzi research through the PSE, with the aim of identifying vaccine, diagnostic, and therapeutic targets, is an important human disease related endeavor.
Project Terms:
abstracting; Acquired Immunodeficiency Syndrome; Address; Adherence; Adopted; Adoption; Adult; Algorithms; Anatomy; Animal Model; Anti-Retroviral Agents; Architecture; Archives; Area; Arts; Automobile Driving; base; Beds; Behavior; biocomputing; Bioinformatics; Biological; Biological Sciences; Biomedical Computing; Biomedical Research; biomedical scientist; Body of uterus; Buffaloes; California; Caring; Chagas Disease; Childhood; Chronic; Clinic; Clinical; Clinical Research; Clinical Trials; Collaborations; college; Communities; Complex; computer based Semantic Analysis; computer science; Computer software; Computer Systems Development; Computers; concept; Controlled Vocabulary; Data; Data Analyses; data integration; Data Set; Data Sources; Databases; design; desire; Development; Diagnostic; Disease; DNA; Doctor of Medicine; Doctor of Philosophy; Doctor of Public Health; Drops; Drosophila genus; Educational Activities; Educational workshop; Electronics; Enrollment; Ensure; Environment; Evaluation; Evolution; Face; Feedback; Foundations; fundamental research; Future; Gene Mutation; Generations; Generic Drugs; Genes; Genetic; Genetic Variation; Genome; Genomics; Geographic Locations; Goals; Health; Heart Diseases; HIV; HIV Infections; Homologous Gene; Human; human disease; Human Resources; Imagery; Immunologic Deficiency Syndromes; Immunology; improved; indexing; Individual; Infection; Informatics; Information Management; Information Resources; Information Services; Information Technology; innovative technologies; International; Internet; Interruption; Knowledge; knowledge base; Laboratories; Laboratory Organism; Language; Latin America; Lead; Learning; Leishmania major; Libraries; Link; Manuals; Maps; Mass Spectrum Analysis; Medical Informatics; Medicine; member; Metabolic Pathway; metabolomics; Metadata; Methodology; Methods; middle age; Mind; Mining; Modeling; Mutation; Natural Language Processing; Nature; novel; novel strategies; Online Mendelian Inheritance In Man; Online Systems; Ontology; open source; Operative Surgical Procedures; Oregon; Organism; Orthologous Gene; Outcome; outreach; pandemic disease; Parasites; pathogen; Pathogenesis; Patients; Peer Review; Pharmaceutical Preparations; Phase; Phenotype; Philosophy; Physiology; prevent; Prevention strategy; Principal Investigator; Problem Solving; Process; programs; protein protein interaction; Proteomics; Protocols documentation; Public Health; Publications; Publishing; PubMed; Purpose; Randomized Clinical Trials; Range; Records; repository; Research; research and development; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; research study; Resources; San Francisco; Science; Scientist; Semantics; Services; Site; Software Tools; Solutions; Source; Standards of Weights and Measures; Structure; Study models; Sudden Death; Sum; syntax; System; TAF8 gene; Talents; Techniques; Technology; Terminology; Testing; theories; therapeutic target; Thinking; tool; Training; Treatment Protocols; Trypanosoma brucei brucei; Trypanosoma cruzi; United States National Institutes of Health; United States National Library of Medicine; Universities; Update; USA Georgia; usability; Vaccines; Vertical Disease Transmission; Victoria Austrailia; Virtual Library; Virus; Western Asia Georgia; Work; Zebrafish

Details

Contact PI / Project Leader Information:
Name:  SHETH, AMIT P
Other PI Information:
Not Applicable
Awardee Organization:
Name:  WRIGHT STATE UNIVERSITY
City:  DAYTON    
Country:  UNITED STATES
Congressional District:
State Code:  OH
District:  07
Other Information:
Fiscal Year: 2008
Award Notice Date: 30-Apr-2008
DUNS Number: 047814256
Project Start Date: 01-May-2008
Budget Start Date: 01-May-2008
CFDA Code: 837
Project End Date: 31-Mar-2012
Budget End Date: 31-Mar-2009
Agency: ?

Agency: The entity responsible for the administering of a research grant, project, or contract. This may represent a federal department, agency, or sub-agency (institute or center). Details on agencies in Federal RePORTER can be found in the FAQ page.

HHS/NIH/National Heart Lung and Blood Institute (NHLBI)
Project Funding Information for 2008:
Year Agency

Agency: The entity responsible for the administering of a research grant, project, or contract. This may represent a federal department, agency, or sub-agency (institute or center). Details on agencies in Federal RePORTER can be found in the FAQ page.

FY Total Cost
2008 NHLBI

HHS/NIH/National Heart Lung and Blood Institute (NHLBI)

$393,930

Results

i

It is important to recognize, and consider in any interpretation of Federal RePORTER data, that the publication and patent information cannot be associated with any particular year of a research project. The lag between research being conducted and the availability of its results in a publication or patent award varies substantially. For that reason, it's difficult, if not impossible, to associate a publication or patent with any specific year of the project. Likewise, it is not possible to associate a publication or patent with any particular supplement to a research project or a particular subproject of a multi-project grant.

ABOUT FEDERAL REPORTER RESULTS

Publications: i

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PubMed = PubMed PubMed Central = PubMed Central Google Scholar = Google Scholar

Patents: i

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