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ETHNO-EPIDEMIOLOGY OF HCV, HIV AND OVERDOSE ASSOCIATED WITH DRUG MARKETSAND DRUG TOURISM

Agency:
NIDA

HHS/NIH/National Institute on Drug Abuse (NIDA)

Project Number:
3R01DA049644-01A1S1
Contact PI / Project Leader:
STRATHDEE, STEFFANIE A.
Awardee Organization:
UNIVERSITY OF CALIFORNIA SAN DIEGO

Description

Abstract Text:
To respond to the burgeoning SARSCoV-2 epidemic, we propose to leverage the infrastructure of a new binational cohort of 600 people who inject drugs (PWID), as well as additional UCSD investigators who have expertise in analysis of social networks, microbiome, and genetic sequencing data to address the proposed aims: Aim 1. To determine the prevalence and correlates of subclinical and symptomatic SARSCoV-2 infection among PWID within the SD/TJ border region. Aim 2. To determine the prevalence and correlates of SARSCoV-2 shedding in nasal secretions and fecal specimens among PWID. Aim 3. To determine network features associated with cross-border transmission of subclinical SARSCoV-2 infection among PWID. Aim 4: To use molecular epidemiology to determine the global migration of SARSCoV-2 between PWID in San Diego and Tijuana and factors associated with local and global dispersal. We will use social network surveys, microbiome analysis and full length SARSCoV-2 sequencing to characterize PWIDs’ social network determinants of SARSCoV-2 infection, the influence of the microbiome on shedding, and the viral genetic migrations within SD, TJ and beyond. Accurate estimates of subclinical infection of SARSCoV-2 and its risk factors are needed to inform prevention, treatment, and public policy, especially in a cross-border context where border closures have already been implemented as a costly measure to curb transmission.
Project Terms:
Address; Characteristics; Cities; Cocaine; cohort; Country; Coupled; Data; Data Collection; Disease Outbreaks; Drug Formulations; drug market; Drug Prescriptions; epidemiologic data; Epidemiology; Ethnography; Female; Fentanyl; Future; Geography; Half-Life; Health; Heating; Hepatitis C Incidence; Hepatitis C virus; Heroin; HIV; HIV/HCV; Incidence; Injecting drug user; Injections; Intervention; Laws; Lead; male; mathematical model; Mediating; Methamphetamine; Mexico; Modeling; Molecular Epidemiology; Monitor; National Institute of Drug Abuse; Needle Sharing; non-drug; Outcome; Overdose; Penetration; Persons; Pharmaceutical Preparations; Powder dose form; prescription opioid; prevent; Preventive Intervention; Price; prospective; Reporting; Research; Risk Behaviors; Route; Sampling; Structure; Syringes; Tars; Testing; Time; trafficking; transmission process; trend; United States National Institutes of Health; Virus

Details

Contact PI / Project Leader Information:
Name:  STRATHDEE, STEFFANIE A.
Other PI Information:
Not Applicable
Awardee Organization:
Name:  UNIVERSITY OF CALIFORNIA SAN DIEGO
City:  LA JOLLA    
Country:  UNITED STATES
Congressional District:
State Code:  CA
District:  52
Other Information:
Fiscal Year: 2020
Award Notice Date: 01-May-2020
DUNS Number: 804355790
Project Start Date: 01-Apr-2020
Budget Start Date: 01-Apr-2020
CFDA Code: 279
Project End Date: 31-Jan-2025
Budget End Date: 31-Jan-2021
Agency: ?

Agency: The entity responsible for the administering of a research grant, project, or contract. This may represent a federal department, agency, or sub-agency (institute or center). Details on agencies in Federal RePORTER can be found in the FAQ page.

HHS/NIH/National Institute on Drug Abuse (NIDA)
Project Funding Information for 2020:
Year Agency

Agency: The entity responsible for the administering of a research grant, project, or contract. This may represent a federal department, agency, or sub-agency (institute or center). Details on agencies in Federal RePORTER can be found in the FAQ page.

FY Total Cost
2020 NIDA

HHS/NIH/National Institute on Drug Abuse (NIDA)

$153,045

Results

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