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Project Information

SYNTHESIS AND INVESTIGATION OF ACYLHYDRAZONE HEMICARCERANDS AND NANOCAPSULES

Agency:
NSF

National Science Foundation

Project Number:
0957611
Contact PI / Project Leader:
WARMUTH, RALF
Awardee Organization:
RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

Description

Abstract Text:
With the support from the Macromolecular, Supramolecular, and Nanochemistry Program in the Division of Chemistry, Prof. Ralf Warmuth of Rutgers University New Brunswick conducts research to construct "dynamic nanocapsules" in water for entrapping proteins and studying the effects of encapsulation on protein activity. Specifically, the Warmuth group is developing methodologies for the one-pot multi-component synthesis of different nanometer-sized molecular capsules using reversible acylhydrazone chemistry. Kinetic and mechanistic investigations will be performed to gain insights into the dynamic features and stability of these capsules. The role of solvents for the formation of these capsules will be examined. In addition, this research group will explore methodologies for the encapsulation of insulin inside a water-soluble rhombicuboctahedral nanocapsule.

The development of thermodynamically controlled synthesis of nanocapsules and the studies of these capsules will advance knowledge in supramolecular chemistry and have impacts on nanoscience and nanotechnology. The investigation of the potential of these nanocapsules to entrap and influence the properties of the encapsulated proteins (especially insulin) would provide insights into methods for controlling protein activities and would broadly impact biological and medical fields. Furthermore, this project will provide multidisciplinary research training for graduate, undergraduate, and high school students.
Project Terms:
Biological; Chemistry; Development; Encapsulated; high school; insight; Insulin; Interdisciplinary Study; Investigation; Kinetics; Knowledge; Medical; Methodology; Methods; Molecular; nanoscale; nanoscience; Nanotechnology; New Brunswick; programs; Property; Proteins; Research; Research Training; Role; Solvents; Students; Universities; Water

Details

Contact PI / Project Leader Information:
Name:  WARMUTH, RALF
Other PI Information:
Not Applicable
Awardee Organization:
Name:  RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK
City:  NEW BRUNSWICK    
Country:  UNITED STATES
Congressional District:
State Code:  NJ
District:  06
Other Information:
Fiscal Year: 2010
Award Notice Date: 30-Aug-2010
DUNS Number: 001912864
Project Start Date: 01-Sep-2010
Budget Start Date:
CFDA Code: 47.049
Project End Date: 31-Aug-2013
Budget End Date:
Agency: ?

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National Science Foundation
Project Funding Information for 2010:
Year Agency

Agency: The entity responsible for the administering of a research grant, project, or contract. This may represent a federal department, agency, or sub-agency (institute or center). Details on agencies in Federal RePORTER can be found in the FAQ page.

FY Total Cost
2010 NSF

National Science Foundation

$390,000

Results

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