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Project Information

RUI: EVOLUTION OF CLITELLATE COCOONS: REGULATION, SECRETION AND ULTRASTRUCTURE

Agency:
NSF

National Science Foundation

Project Number:
0843419
Contact PI / Project Leader:
SHAIN, DANIEL H
Awardee Organization:
RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

Description

Abstract Text:
Clitellate annelids (e.g., earthworms, leeches) contain specialized segments comprising the clitellum, whose primary function is to secrete a cocoon. Clitellate cocoons display remarkable physical properties, including resilience to temperature extremes, proteases and organic chemicals. The primary goals of this project are to characterize cocoon secretion at molecular and cellular levels, and to determine ultrastructural features that distinguish different cocoon types. The central hypothesis is that cocoon-secreting cells are derived from a single precursor cell type that differentiates into two lineages; one secretes protein granules that generate the cocoon membrane, while the other secretes a glycosylated form of the same protein that forms opercula (glue-like plugs that seal the cocoon ends). Employing available DNA and antibodies, an understanding of the evolution and secretion dynamics of the cocoon will be gained that will facilitate their potential applications as biomaterials (e.g., thin, flexible, transparent membranes; underwater adhesives; biopolymers). Student participants will be actively engaged in this research, present results at local, state and national symposia, and gain exposure to this work through its integration into existing 'Computers in Biology' and 'Electron Microscopy' courses at Rutgers-Camden.
Project Terms:
Adhesives; Antibodies; Biocompatible Materials; Biology; Biopolymers; cell type; Cells; Computers; Cytoplasmic Granules; DNA; Electron Microscopy; Evolution; Exposure to; extreme temperature; flexibility; Glues; Goals; Leeches; Membrane; Molecular; Organic Chemicals; Participant; Peptide Hydrolases; Pheretima sieboldi; physical property; precursor cell; Proteins; Regulation; Research; resilience; seal; Students; symposium; Work

Details

Contact PI / Project Leader Information:
Name:  SHAIN, DANIEL H
Other PI Information:
Not Applicable
Awardee Organization:
Name:  RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK
City:  CAMDEN    
Country:  UNITED STATES
Congressional District:
State Code:  NJ
District:  01
Other Information:
Fiscal Year: 2009
Award Notice Date: 06-Mar-2009
DUNS Number: 001912864
Project Start Date: 01-Jul-2009
Budget Start Date:
CFDA Code: 47.074
Project End Date: 30-Jun-2012
Budget End Date:
Agency: ?

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National Science Foundation
Project Funding Information for 2009:
Year Agency

Agency: The entity responsible for the administering of a research grant, project, or contract. This may represent a federal department, agency, or sub-agency (institute or center). Details on agencies in Federal RePORTER can be found in the FAQ page.

FY Total Cost
2009 NSF

National Science Foundation

$291,694

Results

i

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